Oncology

The Surgery Department at St James’s Hospital, has a long established research program. We run a number of both investigator-led and industry centred drug trials. We have new form of cancer treatment called CAR T-cell therapy is now available to patients with lymphoma. Called ‘chimeric antigen receptor’ (CAR) T-cell therapy, this treatment uses the patient’s own immune cells to fight their cancer.

Current Trials & Studies
Study NameStudy TitleStudy TypeSponsorSponsor Type
CartitudeA Phase 3 Randomized Study Comparing Bortezomib, Lenalidomide and Dexamethasone (VRd) followed by Ciltacabtagene, Autoleucel, a Chimeric Antigen Receptor T cell (CAR-T) Therapy directed Against BCMA versus Bortezomib, Lenalidomide, and Dexamethasone (VRd) followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants with newly diagnosed Multiple Myeloma for Whom Hematopoietic Stem Cell Transplant is not Planned as initial therapyClinical trial (NCT04923893) (2021-001242-35)Janssen Commercial: Industry
IPCOR Irish Prostate Cancer Outcomes Research Observational-non invasive Irish Cancer Society & Movember Charity
t-BRCA Upfront systematic tumour BRCA testing in patients with high grade serious or endometrioid ovarian, fallopian tube or primary peritoneal cancer: The t-BRCA Study Observational with invasive tests AstraZeneca Charity
Cares A Phase 1/2 Trial of the Synthetic Cannabinoid ART27.13in Patients with Cancer Anorexia and Weight Loss Clinical trial (2020-000464-27) Artelo Biosciences Limited Commercial: Industry
PERCS Study Personalised Exercise Rehabilitation in Cancer Survivorship: The PERCS Programme Observational-non invasive Irish cancer society Charity
Past Trials & Studies
Study NameStudy TitleStudy TypeSponsorSponsor Type
Restore SWATDevelopment of a patient designed participant information leaflet for the future ReStOre II trial – A Public and Patient Involvement initiativeObservational-non invasive (NCT03958019) N/ANon-commercial: Academic
EndoGut1Characterisation of changes in gut mucosal function after upper gastrointestinal surgery Observational with invasive tests (NCT03734627) N/ANon-commercial: Academic
EndoGut2Characterisation of changes in gut mucosal function after upper gastrointestinal surgery (EndoGut 2) Observational with invasive tests (NCT03734627)N/ANon-commercial: Academic
Buffet Lunch Study on food preferences and satiety post cancer surgeryBuffet Lunch Study on food preferences and satiety post cancer surgeryNutritional TrialNon-commercial: Academic
Barrett's OesophaegusBarrret's Oesophagus Registry: Registry of Irish Patient's with Barrett's and Barrett's OesophagusN/AAcademic
Neo-AEGISRandomised clinical trial in adenocarcinoma of the oesophagus and oesophago-gastric junction: A comparison of neo-adjuvant and adjuvant chemotherapy and surgery versus neo-adjuvant chemoradiation and surgeryClinical TrialSt James’s hospital Academic
Gut Hormones after upper GI surgeryFood intake and gut hormones release in patients in cancer remission who have undergone upper gastrointestinal surgeryObservational with radiology or blood testsN/AAcademic
Upper GI BiobankDelineation of the regulatory networks in upper gastrointestinal cancers using a genome-wide approachObservational with radiology or blood testsN/AAcademic
MAGIC Randomised trial in adenocarcinoma of the oesophagus and oesophago-gastric junction: A comparison of neo-adjuvant and adjuvant chemotherapy and surgery versus neo-adjuvant chemoradiation and surgery (MAGIC) Clinical trial (NCT01726452)HSE/HRB Non-commercial: Academic
PREPAREPREPARE - Preoperative inspiratory muscle training to prevent postoperative pneumonia in patients undergoing esophageal resectionObservational-non invasiveN/AAcademic
Satiety GH Modulation on AppetiteThe effect of satiety gut hormone modulation on appetitive drive after upper gastrointestinal surgeryNutritional TrialN/AAcademic
Longitudinal assessment of gut hormoneLongitudinal assessment of gut hormone secretion following upper gastrointestinal surgery for cancerObservational with radiology or blood testsN/AAcademic
TRANSITCharacterisation of changes in nutrient handling after upper gastrointestinal surgery - TRANSITObservationalN/A Non Commercial: Academic