Neurology

Within the last few years the CRF has forged very strong links with neurologists both in St James’s hospital and Beaumont hospital. The CRF works on epilepsy studies with Dr Doherty.

We have also conducted Phase I overnight studies with Prof Orla Hardiman, researching treatment in motor neuron disease.

Current Trials & Studies
Study Name Study TitleStudy Type SponsorSponsor Type
BIIB078A Phase I Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults with C9ORF72-Associated Amyotrophic Lateral SclerosisClinical Trial (NCT03626012)BiogenCommercial: Industry
CONCUSSIONAssessment of Concussion in contact sportClinical trial (NCT02898610) (2015-004505-16)N/ANon-commercial: Hospital
TMS Characterising Network Disruption in Human Neurodegeneration: A Spectral EEG and TMS based approach in Amyotrophic Lateral Sclerosis Clinical Trial (NCT04918251)Science Foundation Ireland Non-commercial: Academic
PREVENT The PREVENT Research Programme - Pilot and Feasibility Stage Observational with invasive tests University of Edinburgh Non-commercial: Academic
CONCUSSIONAssessment of Concussion in contact sportObservational with radiology or blood testsN/ANon-commercial: Hospital
MotorMarkerimpairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised DiagnosisObservational with radiology or blood testsN/ANon-commercial: Academic
SynaG Identifying Biomarkers for Autism Spectrum Disorder and Neurodevelopmental Disorders in Individual Carriers of Rare Genetic Risk Variants Observational with radiology or blood tests EU Innovative Medicines Scheme Charity
MolGen Whole Genome Sequencing of Multiplex Families afected by Autism Spectrum Disorder and Major Neuropsychiatric Conditions Observational with radiology or blood tests Wellcome Trust Charity
EEG-MMN and EEG-SARTCharacterising Network Disruption in Human Neurodegeneration: A Spectral EEG and TMS based approach in Amyotrophic Lateral SclerosisObservational-non invasiveN/ANon-commercial: Academic
GMI AZD The Genomic Basis of Alzheimer's disease in Ireland Observational with radiology or blood tests GMI Commercial: Industry
BIOVASC The BIOVASC Study (Biomarkers and Imaging Of Vulnerable Atherosclerosis in Symptomatic Carotid artery disease) Observational with invasive tests Neurovascular Research Centre, UCD Non-commercial: Academic
Past Trials & Studies
Study NameStudy TitleStudy TypeSponsorSponsor Type
UCB StudyA Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study To Evaluate The Efficacy And Safety Of Padsevonil As Adjunctive Treatment Of Focal-Onset Seizures In Adult Subjects With Drug-Resistant EpilepsyClinical trial (NCT03739840)UCBIndustry
Renew Renew Research, LLC - RenewTM NCP-5 - 1001, A Randomized Pivotal Study of RenewTM NCP-5 for the Treatment of Mild Cognitive Impairment due to Alzheimer's Disease or Mild Dementia of the Alzhemier's Type (Pro00027434) Medical device study (NCT03721705) Renew Commercial: Industry
EEG in ALS PatientsHigh resolution Spectral EEG recording in Amyotrophic lateral sclerosis; correlation with comprehensive neuropsychological profilingObservational with invasive testsN/AAcademic
EEG and epilepsyThe Acute neroimaging, neurophysiology and clinical data correlation in patients presenting to the emergency Department within 24 hours of seizure onset and at 6 weeks post ictallyObservational with invasive testsN/AAcademic
IHF Stroke Biomarker (DCCR) IHF Stroke Biomarker Observational with radiology or blood tests National (Government agency)
IMAGEN IMAGEN Study Observational with radiology or blood tests Non-commercial: Academic
BIOMARKAPD BIOMARKAPD- A pilot study on the utility of CSF and blood biomarkers in the delineation of the aetiopathology of cognitive impairment and in the prediction of conversion of mild cognitive impairment to dementia. Observational with radiology or blood tests National (Government agency)
NILVAD NILVAD - A European Multicentre Double Blind Placebo Controlled trial of Nilvadipine in Mild to Moderate Alzhelmer's disease Clinical trial (NCT02017340)European Commission: FP7 Grant Non-commercial: Academic
MCI Evoked Potentials (Eps) used in clinical practice Observational with invasive tests Health Research Board National (Government agency)
Evoked EPs Evoked Potentials (Eps) used in clinical practice Observational with radiology or blood tests Medical Directorate Non-commercial: Hospital