Neurology

Within the last few years the CRF has forged very strong links with neurologists both in St James’s hospital and Beaumont hospital. The CRF works on epilepsy studies with Dr Doherty.

We have also conducted Phase I overnight studies with Prof Orla Hardiman, researching treatment in motor neuron disease.

Current Trials & Studies
Study Name Study TitleStudy Type SponsorSponsor Type
Fusion A Phase 1-3 Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ION363 in Amyotrophic Lateral Sclerosis Patients with Fused in Sarcoma Mutations (FUS-ALS) Clinical trial (NCT04768972)Ionis Pharmaceuticals Commercial: Industry
Anqur A MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED MULTIPLE-ASCENDING DOSE STUDY TO EVALUATE THE SAFETY AND TOLERABILITY OF QRL-201 IN AMYOTROPHIC LATERAL SCLEROSIS Clinical trial (NCT05633459)QurAlis Corporation Commercial: Industry
Clou A randomized, double-blind, double- dummy, parallel-group study, comparing the efficacy and safety of remibrutinib versus teriflunomide in participants with relapsing multiple sclerosis, followed by xtended treatment with open-label remibrutinib Clinical trial (NCT05147220)Novartis Commercial: Industry
AVP-786 A Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy, safety, and tolerability of AVP-786 (deudextromethorphan hydrobromide [d6-DM]/quinidine sulfate [Q]) for the treatment of agitation in patients with dementia of the Alzheimer’s type Clinical trial (NCT03393520)Avanir Pharmaceuticals Commercial: Industry
EMG studies initiative EMG studies initiative (tests will be carried out according to usual clinical practice) Observational-non invasiveTCD and MND Charity Non-commercial: Academic
RECONNECT (Zynerba) A Randomized, Double-Blind, Placebo-Controlled, Multiple-Centre Efficacy and Safety Study of ZYN002 Administered as a Transdermal Gel to Children and Adolescents with Fragile X Syndrome - RECONNECT Clinical Trial (NCT03614663)ZynerbaCommercial: Industry
CDKL5 Deficiency Disorder (CDD)Analysis of alpha-tubulin post-translational modifications using infra-red western blot in plasma sampled from CDKL5 Deficiency Disorder (CDD) patientsObservational-non invasiveNon-commercial: Hospital University
TMS Characterising Network Disruption in Human Neurodegeneration: A Spectral EEG and TMS based approach in Amyotrophic Lateral Sclerosis Clinical Trial (NCT04918251)Science Foundation Ireland Non-commercial: Academic
PREVENT The PREVENT Research Programme - Pilot and Feasibility Stage Observational with invasive tests University of Edinburgh Non-commercial: Academic
CONCUSSIONAssessment of Concussion in contact sportObservational with radiology or blood testsN/ANon-commercial: Hospital
MotorMarkerimpairments of Neuro-muscular Communication in Motor-Neuron Disease: A Bio-Marker for Early and Personalised DiagnosisObservational with radiology or blood testsN/ANon-commercial: Academic
EEG-MMN and EEG-SARTCharacterising Network Disruption in Human Neurodegeneration: A Spectral EEG and TMS based approach in Amyotrophic Lateral SclerosisObservational-non invasiveN/ANon-commercial: Academic
GMI AZD The Genomic Basis of Alzheimer's disease in Ireland Observational with radiology or blood tests GMI Commercial: Industry
EVOKEA randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE)Clinical Trial (NCT04777396)Novo NordiskCommercial: Industry
EVOKE PlusA randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE plus)Clinical Trial (NCT04777409)Novo NordiskCommercial: Industry
Past Trials & Studies
Study NameStudy TitleStudy TypeSponsorSponsor Type
WaveA Multicenter, Randomized, Double-blind, Placebocontrolled,Phase 1b/2a Study of WVE-004Administered Intrathecally to Patients with C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) orFrontotemporal Dementia (FTD)Clinical trial (NCT04931862)Wave Life SciencesCommercial: Industry
SynaG Identifying Biomarkers for Autism Spectrum Disorder and Neurodevelopmental Disorders in Individual Carriers of Rare Genetic Risk Variants Observational with radiology or blood tests EU Innovative Medicines Scheme Charity
BIOVASCThe BIOVASC Study (Biomarkers and Imaging Of Vulnerable Atherosclerosis in Symptomatic Carotid artery disease)Observational with invasive testsNeurovascular Research Centre, UCDNon-commercial: Academic
MolGenWhole Genome Sequencing of Multiplex Families afected by Autism Spectrum Disorder and Major Neuropsychiatric ConditionsObservational with radiology or blood tests Wellcome TrustCharity
BIIB078A Phase I Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 Administered Intrathecally to Adults with C9ORF72-Associated Amyotrophic Lateral SclerosisClinical Trial (NCT03626012)BiogenCommercial: Industry
UCB StudyA Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study To Evaluate The Efficacy And Safety Of Padsevonil As Adjunctive Treatment Of Focal-Onset Seizures In Adult Subjects With Drug-Resistant EpilepsyClinical trial (NCT03739840)UCBIndustry
Renew Renew Research, LLC - RenewTM NCP-5 - 1001, A Randomized Pivotal Study of RenewTM NCP-5 for the Treatment of Mild Cognitive Impairment due to Alzheimer's Disease or Mild Dementia of the Alzhemier's Type (Pro00027434) Medical device study (NCT03721705) Renew Commercial: Industry
EEG in ALS PatientsHigh resolution Spectral EEG recording in Amyotrophic lateral sclerosis; correlation with comprehensive neuropsychological profilingObservational with invasive testsN/AAcademic
EEG and epilepsyThe Acute neroimaging, neurophysiology and clinical data correlation in patients presenting to the emergency Department within 24 hours of seizure onset and at 6 weeks post ictallyObservational with invasive testsN/AAcademic
IHF Stroke Biomarker (DCCR) IHF Stroke Biomarker Observational with radiology or blood tests National (Government agency)
IMAGEN IMAGEN Study Observational with radiology or blood tests Non-commercial: Academic
BIOMARKAPD BIOMARKAPD- A pilot study on the utility of CSF and blood biomarkers in the delineation of the aetiopathology of cognitive impairment and in the prediction of conversion of mild cognitive impairment to dementia. Observational with radiology or blood tests National (Government agency)
NILVAD NILVAD - A European Multicentre Double Blind Placebo Controlled trial of Nilvadipine in Mild to Moderate Alzhelmer's disease Clinical trial (NCT02017340)European Commission: FP7 Grant Non-commercial: Academic
MCI Evoked Potentials (Eps) used in clinical practice Observational with invasive tests Health Research Board National (Government agency)
Evoked EPs Evoked Potentials (Eps) used in clinical practice Observational with radiology or blood tests Medical Directorate Non-commercial: Hospital