Intensive Care

St James’s hospital has the largest Intensive Care Unit capacity in Ireland. The CRF in conjunction with the intensive care unit manages both investigator led studies and clinical trials.

Dr Ignacio Martin-Leoches is particularly interested in sepsis and researching how best to treat this in an acute ICU setting.

Current Trials & Studies
Study Name Study TitleStudy TypeSponsorSponsor Type
InoTrem ASTONISHEfficacy, Safety and Tolerability of Nangibotide in Patients with Septic Shock. A Randomized, Double-blind, Placebo Controlled Dose Selection Study Clinical TrialINOTREM S.A.Industry
REMAP-CAPRandomized, Embedded, Multifactorial Adaptive Platform trial for Community Acquired Pneumonia Clinical TrialAcademic
Alfa-1A randomized double blind placebo- controlled, pilot trial of intravenous plasma-purified alpha 1 antitrypsin for severe COVID-19 illness Clinical TrialRoyal College of SurgeonsNon-commercial: Academic
Past Trials & Studies
Study NameStudy TitleStudy TypeSponsorSponsor Type
CUBIST A prospective randomised double blind multicentre phase 3 study to assess the safety and efficacy of IV ceftolozane/tazobactram compared to meropenem in adult patients with ventilated nosocomial pneumoniaClinical trialCubist PharmaceuticalsIndustry
EVADEA Phase 2 Proof-of-concept Study to Evaluate the Efficacy and Safety of MEDI3902 in Mechanically Ventilated Patients for the Prevention of Nosocomial Pneumonia Caused by Pseudomonas aeruginosaClinical trialMedimmuneIndustry
TAMETargeted therapeutic mild hypercapnia after resusictated cardiac arrest: A phase III multi-centre randomized controlled trialClinical trialANZIC Non commercial
SPICE IIIA Prospective Multicentre RCT of Early Goal Directed Sedation Compared with Standard Care in Mechanically Ventilated Patients in Intensive CareOtherANZICNon-commercial
TransfuseStandard issue transfusion versus fresher red blood cell use in intensive care - a randomized controlled trialObservational with invasive testsANZICNon-commercial