Intensive Care

St James’s hospital has the largest Intensive Care Unit capacity in Ireland. The CRF in conjunction with the intensive care unit manages both investigator led studies and clinical trials.

Dr Ignacio Martin-Leoches is particularly interested in sepsis and researching how best to treat this in an acute ICU setting.

Current Trials & Studies
Study Name Study TitleStudy TypeSponsorSponsor Type
The Sepsis Study Developing a hybrid evolvable disease sensor for sepsis Observational with radiology or blood tests St. James's hospital National (Government agency)
Past Trials & Studies
Study NameStudy TitleStudy TypeSponsorSponsor Type
Revival Trial A Randomized, Double-Blind, Placebo-Controlled, Two-Arm Parallel-Group, Multi-Center Phase 3 Pivotal Trial to Investigate the Efficacy and Safety of Recombinant Human Alkaline Phosphatase for Treatment of Patients with Sepsis Associated Acute Kidney Injury Clinical trial (NCT04411472)AM-Pharma B.V. Commercial: Industry
CUBIST A prospective randomised double blind multicentre phase 3 study to assess the safety and efficacy of IV ceftolozane/tazobactram compared to meropenem in adult patients with ventilated nosocomial pneumoniaClinical trial (NCT02070757)Cubist PharmaceuticalsIndustry
EVADEA Phase 2 Proof-of-concept Study to Evaluate the Efficacy and Safety of MEDI3902 in Mechanically Ventilated Patients for the Prevention of Nosocomial Pneumonia Caused by Pseudomonas aeruginosaClinical trial (NCT02696902)MedimmuneIndustry
TAMETargeted therapeutic mild hypercapnia after resusictated cardiac arrest: A phase III multi-centre randomized controlled trialClinical trial (NCT03114033)ANZIC Non commercial
SPICE IIIA Prospective Multicentre RCT of Early Goal Directed Sedation Compared with Standard Care in Mechanically Ventilated Patients in Intensive CareOther (NCT01728558)ANZICNon-commercial
TransfuseStandard issue transfusion versus fresher red blood cell use in intensive care - a randomized controlled trialObservational with invasive tests (NCT01638416)ANZICNon-commercial