The Hepatology Department at St James’s hospital, has a long established research program and runs a variety of both clinical trials and investigator led studies.

Current Trials & Studies
Study NameStudy TitleStudy TypeSponsorSponsor Type
ESSENCEThe effect of semaglutide in subjects with non-cirrhotic non-alcoholic steatohepatitis Clinical Trial (NCT04822181)Novo Nordisk Commercial: Industry
Past Trials & Studies
Study NameStudy TitleStudy TypeSponsorSponsor Type
NUT-3/NASDouble-blind, randomised, placebo controlled, phase IIb clinical trial on the efficacy and safety of norursodeoxycholic acid tablets in patients with non-alcoholic steatohepatitis (NASH)Clinical Trial (2018-003443-31)Dr Falk Pharma GmbHCommercial: Industry
Intercept A Phase 2, Double- Blind Randomized, Parallel- Group Study Evaluating the Efficacy, Safety and Tolerability of Obeticholic Acid, Administrated Alone or in Combination with Bezafibrate, in subjests with Primary Biliary Cholangitis who had an Inadequate Response or who were Unable to Tolerate Ursodeoxycholic Acid Clinical trial Intercept Pharmaceutials Commercial: Industry
Abbvie M16-135A Single Arm, Open-label Study to Evaluate the Efficacy and Safety of Glecaprevir (GLE)/Pibrentasvir (PIB) in Treatment Naïve Adults with Chronic Hepatitis C Virus (HCV) Genotype 1,2, 4, 5 or 6 Infection and Compensated CirrhosisClinical Trial (NCT03089944) (2016-004967-38)AbbVieCommercial: Industry
NASHA multi-centre, double blind placebo controlled, parallel randomised phase Iia study to investigate the safety, tolerability, pharmacodynamics & pharmacokinetics of different doses of orally administered BI 1467335 during a 12 week period compared to placebo in patients with clinical evidence of NASHClinical Trial (NCT03166735) (2016-000499-83)Boehringer IngeilheimCommercial: Industry
HCV and Physical ActivityA determination of the relationship between physical activity, cardiovascular risk factors and metabolic profile in adults with Hepatitis CObservational-non invasiveNon-commercial: Academic
Intensive PK StudyDirect Acting Antivirals in Hepatitis C- Developing a personalized model of care: Intensive PK sub-studyObservational with radiology or blood testsNon-commercial: Academic
CANDIViral Hepatitis C Associated Neurocognitive Dysfunction in Ireland in the direct acting antiviral (DAA) era Observational-non invasiveNon-commercial: Academic
NAFLD Exercise InterventionNon-alcoholic Fatty Liver Disease Exercise Intervention ProtocolOtherNon-commercial: Academic