Dermatology
The Dermatology Department at St James’s hospital, has a long-established research program over the last 19 years. At all stages the research program is supported by the CRF. Our work centres on the most common inflammatory skin condition in adults, namely atopic dermatitis (eczema), and rare genetic skin disorders.
We run several investigator-led and industry centred drug trials for adults with eczema and for genetic skin disorders.
Our outlook is to continue to work on parallel mechanistic studies and early stage clinical trials, all with the aim of bringing better treatments to patients with debilitating skin diseases.
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| A-STAR | The UK-Irish Atopic Eczema Systemic TherApy Register | Observational with radiology or blood tests | British Association of Dermatologists | Non-commercial: Academic |
| Measure Up 2 M18-891 | A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study to Evaluate Upadacitinib in Adolescent and Adult Stubjects with Moderate to Severe Atopic Dermatitis | Clinical Trial (NCT03607422) (2018-001383-28) | Abbvie | Sponsor |
| AD Up M16-047 | Moderate to Severe Atopic Dermatitis: Evaluation of Upadacitinib in Combination with Topical Corticosteroids in Adolescent and Adult Subjects | Clinical Trial (NCT03568318) (2017-005126-37) | Abbvie | Industry Sponsored |
| Targ Staph | Targeting staphylococci adhesion and colonization on the surface of corneocytes in Atopic Dermatitis | Observational Study | Loreal SA | Non-commercial: Academic |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| ABT in Urticaria | Health through attention based training (ABT) for patients in SJH with urticaria | Observational-non invasive | N/A | Non-commercial: Academic |
| SERENA | Long term observational, prospective study to collect in a real life setting data on the retention, effectiveness, safety, treatment pattern, quality of life and efficiency of secukinumab in adult patients with moderate to severe plaque psoriasis | Non-Interventional Study | Novartis | Industry Sponsored |
| Measure AD | Global cross-sectional burden of illness study in adolescent and adult patients with atopic dermatitis | Non-Interventional Study | Abbvie | Industry Sponsored |
| R668-AD-1424 | A Phase 3 Study Investigating the Efficacy, Safety, and Tolerability of Dupilumab Administered to Adult Patients with Severe Atopic Dermatitis who are not Adequately Controlled with or are Intolerant to Oral Cyclosporine A, or when this Treatment is not Medically Advisable | Clinical trial (NCT02755649) | Regeneron | Industry |
| R668-AD-1225 Open Label | An open-label study of Dupilumab in Patients with Atopic Dermatitis who participated in previous Dupilumab Clinical Trials | Clinical trial (NCT01949311) (2013-001449-15) | Regeneron | Industry |
| Phase Dermatitis | A Phase 3 study investigating the efficacy, safety and tolerability of dupilumab administered to adult patients with severe atopic dermatitis who are not adequately controlled with or are intolerant to oral cyclosporine A, or when this treatment is not medically advisable | Clinical trial (NCT02755649) (2015-002653-35) | Regeneron Pharmaceuticals Inc | Industry |
| EASE | Double-blind, Randomised, Vehicle-Controlled, Phase III, Efficacy and Safety Study with 24-month Open-label Follow-up of Oleogel-S10 in patients with Inherited Epidermolysis Bullosa | Clinical trial (NCT03068780) (2016-002066-32) | Amryt Research Ltd | Industry |
| Neutro Pro | The role of neutrophil proteases as global regulators of IL-1 family cytokine activity in psoriasis | Observational with radiology or blood tests | SFI | Non-commercial: Academic |
| CAPS | MCC950 and Derivatives in CAPs patients | Observational with radiology or blood tests | Inflazome Ltd. | Commercial: Industry |
| Ostoform | Ostoform Patient Study | Medical device study | Ostoform | Commercial: Industry |