The Cardiology  Department  at St James’s hospital is actively involved in clinical research. We run both clinical trials and investigator led studies in amyloidosis, dyslipidemia and heart failure.

Current Trials & Studies
Study NameTitle StudyStudy TypeSponsorSponsor Type
MK-1242 in Chronic Heart Failure (VICTOR) A Pivotal Phase 3 Randomized, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of the sGC Stimulator Vericiguat/MK-1242 in Adults with Chronic Heart Failure With Reduced Ejection Fraction with Chronic Heart Failure With Reduced Ejection Fraction Clinical trial (NCT05093933) Merck Sharp & Dohme Corp Commercial: Industry
Victorion Plaque A multi-center, randomized, double-blind, placebocontrolled, parallel-group Phase IIIb study evaluating the effect of inclisiran on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of non-obstructive coronary artery disease without previous cardiovascular events (VICTORION-PLAQUE)Clinical trial (NCT05360446)Novartis Pharma AG Commercial: Industry
Fast III Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR guided revascularization Clinical trial (NNCT04931771)Ernest Spitzer Non-commercial: Hospital
Fontan Exercise A Single-centre, prospective case control study evaluating the impact of a standardised aerobic and strength exercise regime on exercise capacity, ventricular function and perceived quality of life in paediatric Fontan patients.Observational studyChildren research seed fundNon-commercial: Hospital
ATTR-CMAn observational study investigating the disease penetrance of hereditary transthyretin amyloid cardiomyopathy (ATTR-CM) using genetic cascade screening and multimodality imaging tecniques. Observational StudyPfizer Non Commercial: Hospital
RHEIAA Prospective, Randomized, Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Transcatheter Aortic Valve Implantation as compared to surgery in Female Patients who have Severe Symptomatic Aortic Stenosis Requiring Aortic Valve Replacement Patients Medical Device study (NCT04160130)SS International Clinical Research Commercial : Industry
Past Trials & Studies
Study NameStudy TitleStudy TypeSponsorSponsor Type
HELIOSA Study to Evaluate Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy Clinical Trial (NCT03759379)AlnylamIndustry
CroiValve A Study of the Feasibility, Safety and Performance of Temporary Implantation of the CroíValve Coaptation Valve for Evaluation of Correction of Severe Tricuspid Incompetence in Human Patients Medical Device StudyCroiValveCommercial: Industry
ETNANon-interventional Study on Edoxaban Treatment in Routine Clinical Practice for Patients with Non-Valvular Atrial Fibrillation Observational Study (NCT02944019) Daiichi Sankyo, Inc Commercial Industry
Pfizer-ATTR -CMBurden of Disease (BOD) Study in ATTR-CM Patients and CaregiversObservational-non invasivePfizer Commercial: Industry
SANTORINITreatment of High and Very high riSk dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events in Europe – a MultInatioNal ObservatIonal Study (SANTORINI)Non-Interventional studyDaiichi Sankyo Europe GmbHAcademic
EDifyEffect of ivabradine versus placebo on cardiac function, exercise capacity and neuroendocrine activation in patients with Chronic Heart Failure with Preserved left ventricular Ejection Fraction. Find out more: trialServierIndustry
ASPIREIreland-Aspire Survey of Cardiovascular Disease Prevention and DiabetesNon-interventionalAcademic
IHF ASA IHF Aspirin Study (DCCR) Observational with radiology or blood tests Charity Irish Heart Foundation Charity
ARIADNEAssessment of Real Life Care - Describing European Heart Failure Management (ARIADNE)Non-interventionalNovartisIndustry
Lab study novel biomarkers Novel Markers of Plaque Rupture and Platelet Activation in Patients with Chest Pain Observational with radiology or blood tests Health Research Board Non-commercial: Academic
TAMETargeted therapeutic mild hypercapnia after resusictated cardiac arrest: A phase III multi-centre randomized controlled trialClinical trial HRB Non-commercial: Academic