Cardiology
The Cardiology Department at St James’s hospital is actively involved in clinical research. We run both clinical trials and investigator led studies in amyloidosis, dyslipidemia and heart failure.
| Study Name | Title Study | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| MK-1242 in Chronic Heart Failure (VICTOR) | A Pivotal Phase 3 Randomized, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of the sGC Stimulator Vericiguat/MK-1242 in Adults with Chronic Heart Failure With Reduced Ejection Fraction with Chronic Heart Failure With Reduced Ejection Fraction | Clinical trial (NCT05093933) | Merck Sharp & Dohme Corp | Commercial: Industry |
| Victorion Plaque | A multi-center, randomized, double-blind, placebocontrolled, parallel-group Phase IIIb study evaluating the effect of inclisiran on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA) in participants with a diagnosis of non-obstructive coronary artery disease without previous cardiovascular events (VICTORION-PLAQUE) | Clinical trial (NCT05360446) | Novartis Pharma AG | Commercial: Industry |
| Fast III | Fractional Flow Reserve or 3D-Quantitative-Coronary-Angiography Based Vessel-FFR guided revascularization | Clinical trial (NNCT04931771) | Ernest Spitzer | Non-commercial: Hospital |
| Fontan Exercise | A Single-centre, prospective case control study evaluating the impact of a standardised aerobic and strength exercise regime on exercise capacity, ventricular function and perceived quality of life in paediatric Fontan patients. | Observational study | Children research seed fund | Non-commercial: Hospital |
| ATTR-CM | An observational study investigating the disease penetrance of hereditary transthyretin amyloid cardiomyopathy (ATTR-CM) using genetic cascade screening and multimodality imaging tecniques. | Observational Study | Pfizer | Non Commercial: Hospital |
| RHEIA | A Prospective, Randomized, Controlled, Multi-Center Study to Evaluate the Safety and Efficacy of Transcatheter Aortic Valve Implantation as compared to surgery in Female Patients who have Severe Symptomatic Aortic Stenosis Requiring Aortic Valve Replacement Patients | Medical Device study (NCT04160130) | SS International Clinical Research | Commercial : Industry |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| HELIOS | A Study to Evaluate Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy | Clinical Trial (NCT03759379) | Alnylam | Industry |
| CroiValve | A Study of the Feasibility, Safety and Performance of Temporary Implantation of the CroíValve Coaptation Valve for Evaluation of Correction of Severe Tricuspid Incompetence in Human Patients | Medical Device Study | CroiValve | Commercial: Industry |
| ETNA | Non-interventional Study on Edoxaban Treatment in Routine Clinical Practice for Patients with Non-Valvular Atrial Fibrillation | Observational Study (NCT02944019) | Daiichi Sankyo, Inc | Commercial Industry |
| Pfizer-ATTR -CM | Burden of Disease (BOD) Study in ATTR-CM Patients and Caregivers | Observational-non invasive | Pfizer | Commercial: Industry |
| SANTORINI | Treatment of High and Very high riSk dyslipidemic pAtients for the PreveNTion of CardiOvasculaR Events in Europe – a MultInatioNal ObservatIonal Study (SANTORINI) | Non-Interventional study | Daiichi Sankyo Europe GmbH | Academic |
| EDify | Effect of ivabradine versus placebo on cardiac function, exercise capacity and neuroendocrine activation in patients with Chronic Heart Failure with Preserved left ventricular Ejection Fraction. Find out more: https://clinicaltrials.gov/ct2/show/NCT00757055?term=ivabradine&cntry=IE&draw=2&rank=1 | Clinical trial | Servier | Industry |
| ASPIRE | Ireland-Aspire Survey of Cardiovascular Disease Prevention and Diabetes | Non-interventional | Academic | |
| IHF ASA | IHF Aspirin Study (DCCR) | Observational with radiology or blood tests | Charity Irish Heart Foundation | Charity |
| ARIADNE | Assessment of Real Life Care - Describing European Heart Failure Management (ARIADNE) | Non-interventional | Novartis | Industry |
| Lab study novel biomarkers | Novel Markers of Plaque Rupture and Platelet Activation in Patients with Chest Pain | Observational with radiology or blood tests | Health Research Board | Non-commercial: Academic |
| TAME | Targeted therapeutic mild hypercapnia after resusictated cardiac arrest: A phase III multi-centre randomized controlled trial | Clinical trial | HRB | Non-commercial: Academic |