Oncology Gastro-enterology
The Surgery Department at St James’s Hospital, has a long established research program. We run a number of both investigator-led and industry centred drug trials, mostly related to oesophageal cancer. This includes a major international randomised clinical trial (Neo-AEGIS), as well as trials of preoperative fitness and conditioning, and studies on appetite and satiety in weight losing patients in survivorship.
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| Unintentional Weight Loss and Oesophagectomy | Mechanism and Treatment of Unintentional Weight Loss after Oesophagectomy with Curative intent | Observational with radiology or blood tests | Non-commercial: Academic | |
| The PRE-HIIT Trial | Preoperative Exercise to Improve Fitness in Patients Undergoing Complex Surgery for Cancer of the Lung or Oesophagus: The PRE-HIIT Trial | Observational with radiology or blood tests | Non-commercial: Academic | |
| Restore SWAT | Development of a patient designed participant information leaflet for the future ReStOre II trial – A Public and Patient Involvement initiative | Observational-non invasive (NCT03958019) | N/A | Non-commercial: Academic |
| ReStOre II | Rehabilitation Strategies following Oesophagogastric and Hepatopancreaticobiliary Cancer: ReStOreII - A Randomised Controlled Trial | Observational with radiology or blood tests (NCT03958019) | N/A | Non-commercial: Academic |
| Vedolizumab | Impact of Induction Vedolizumab pharmacokinetics on Induction and maintenance therapy outcome in inflammatory bowel disease | Observational with radiology or blood tests | Takeda | Industry |
| Study Name | Study Title | Study Type | Sponsor | Sponsor Type |
|---|---|---|---|---|
| EndoGut1 | Characterisation of changes in gut mucosal function after upper gastrointestinal surgery | Observational with invasive tests (NCT03734627) | N/A | Non-commercial: Academic |
| EndoGut2 | Characterisation of changes in gut mucosal function after upper gastrointestinal surgery (EndoGut 2) | Observational with invasive tests (NCT03734627) | N/A | Non-commercial: Academic |
| Buffet Lunch Study on food preferences and satiety post cancer surgery | Buffet Lunch Study on food preferences and satiety post cancer surgery | Nutritional Trial | Non-commercial: Academic | |
| Barrett's Oesophaegus | Barrret's Oesophagus Registry: Registry of Irish Patient's with Barrett's and Barrett's Oesophagus | N/A | Academic | |
| Neo-AEGIS | Randomised clinical trial in adenocarcinoma of the oesophagus and oesophago-gastric junction: A comparison of neo-adjuvant and adjuvant chemotherapy and surgery versus neo-adjuvant chemoradiation and surgery | Clinical Trial | St James’s hospital | Academic |
| Gut Hormones after upper GI surgery | Food intake and gut hormones release in patients in cancer remission who have undergone upper gastrointestinal surgery | Observational with radiology or blood tests | N/A | Academic |
| Upper GI Biobank | Delineation of the regulatory networks in upper gastrointestinal cancers using a genome-wide approach | Observational with radiology or blood tests | N/A | Academic |
| MAGIC | Randomised trial in adenocarcinoma of the oesophagus and oesophago-gastric junction: A comparison of neo-adjuvant and adjuvant chemotherapy and surgery versus neo-adjuvant chemoradiation and surgery (MAGIC) | Clinical trial (NCT01726452) | HSE/HRB | Non-commercial: Academic |
| PREPARE | PREPARE - Preoperative inspiratory muscle training to prevent postoperative pneumonia in patients undergoing esophageal resection | Observational-non invasive | N/A | Academic |
| Satiety GH Modulation on Appetite | The effect of satiety gut hormone modulation on appetitive drive after upper gastrointestinal surgery | Nutritional Trial | N/A | Academic |
| Longitudinal assessment of gut hormone | Longitudinal assessment of gut hormone secretion following upper gastrointestinal surgery for cancer | Observational with radiology or blood tests | N/A | Academic |
| ReStore | Rehabilitation following Oesophageal cancer: Identifying Rehabilitative Needs and Strategies | Observational-non invasive | N/A | Academic |
| TRANSIT | Characterisation of changes in nutrient handling after upper gastrointestinal surgery - TRANSIT | Observational | N/A | Non Commercial: Academic |